Sevel 800mg 12pcs Tablet

✔️ Uses of Sevel 800

• Treat High phosphate levels in blood

✔️ Side Effects of Sevel 800

Abdominal pain, Diarrhea, Flatulence, Vomiting, Constipation, Nausea, Dyspepsia

✔️ How does Sevel 800 work?

Sevelamer inhibits the absorption of phosphate from the intestine and lowers the phosphate levels in the blood. Sevelamer inhibits the absorption of phosphate from the intestine and lowers the phosphate levels in the blood.

✔️ Direction for use of Sevel 800

Take Sevel 800 as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide on an appropriate dose and duration of Sevel 800 for you depending on your age, body weight, and disease condition. Do not stop taking Sevel 800 unless your doctor advises you to stop.

✔️ Quick Suggestions:

• Take Sevel with meals as directed.
• Regularly monitor serum phosphorus levels and adhere to the prescribed diet.
• Avoid taking other medications close to Sevel dosing times to prevent interaction.

✔️ Indication of Sevel 800

Sevelamer is used in the treatment of High phosphate levels in blood. It is used in patients with kidney problems and on dialysis.

✔️ Pharmacology

Sevelamer carbonate is a non-absorbed phosphate-binding polymer free of metals and calcium. It binds phosphate in the gastrointestinal tract through ionic and hydrogen bonding, reducing phosphate absorption and lowering serum phosphorus levels.

✔️ Dosage & Administration of Sevel 800

• Starting Dose:
  • 2.4 g (Three 800 mg tablets or sachets) or 4.8 g (Six 800 mg tablets or sachets) daily, taken three times a day with meals.
• Titration and Maintenance:
  • Adjust dose based on serum phosphorus levels every 2-4 weeks until target levels are achieved. An average daily dose is about 6 g.
• For patients switching from other phosphate binders:
  • Adjust the dose on a gram-for-gram basis and monitor serum phosphorus.
• Pediatric: Not recommended for children under 18 years. Limited effectiveness was noted in children <13 years and those not on dialysis.
• Geriatric: Insufficient data for patients aged 65 and over; no significant differences noted, but cautious dosing is recommended.

✔️ Before taking Sevel 800, tell your doctor if you:

• Have trouble swallowing
• Have motility problems in the stomach and bowel, like severe constipation
• Have bowel inflammation
• Have undergone major bowel surgery
• Frequently become sick

✔️ Missed dose of Sevel 800

If you miss a dose of Sevel 800, skip it and continue with your normal schedule. Do not double the dose.

✔️ Overdosage of Sevel 800

If you or anyone else accidentally takes too much of Sevel 800, consult your doctor immediately or visit the nearby hospital. 

✔️ Interaction

• Ciprofloxacin: Avoid simultaneous use; can decrease ciprofloxacin's bioavailability by about 50%.
• Other Drugs: May affect absorption of ciclosporin, mycophenolate mofetil, tacrolimus, and levothyroxine. Monitor levels closely if used together.
• Anti-Arrhythmic and Anti-Seizure Medications: Exercise caution; these were not studied in clinical trials.
• General: Administer other medications at least 1 hour before or 3 hours after Sevel to avoid reduced bioavailability.

✔️ Contraindications

• Bowel obstruction.
• Hypersensitivity to Sevelamer carbonate, Sevelamer hydrochloride, or any excipients

✔️ Pregnancy & Lactation

• Pregnancy: Not systemically absorbed; however, it may decrease serum levels of fat-soluble vitamins and folic acid.
• Lactation: Not expected to be absorbed by the child; may also decrease serum levels of fat-soluble vitamins and folic acid.

✔️ Precautions & Warnings

• Dysphagia and Swallowing Disorders: Use with caution in patients with difficulty swallowing.
• Severe GI Motility Disorders: Caution in patients with severe gastrointestinal motility issues.
• Active Inflammatory Bowel Disease: Exercise caution in patients with active inflammatory bowel disease.
• Major GI Tract Surgery: Be cautious in patients who have undergone major gastrointestinal surgery.
• Pregnancy: Sevel is not absorbed systemically; however, it may decrease serum levels of fat-soluble vitamins and folic acid.
• Lactation: Not absorbed systemically or excreted in breast milk; however, it may still affect vitamin levels in the mother.

Monitoring Parameters:

• Serum Levels: Regular monitoring of phosphate, calcium (Ca), chloride (Cl), and bicarbonate levels is required.
• Vitamin Supplementation: Monitor for reductions in vitamins D, E, K, and folic acid, and provide supplements if necessary.
• Peritonitis: In patients undergoing peritoneal dialysis, monitor for signs and symptoms of peritonitis.

✔️ Storage:

Store in a cool, dry place, protected from light.